תזונה ותוספים Antioxidant Supplementation Reduces Skeletal Muscle Mitochondrial Biogenesis.

[Mike Bikov]

Med Sci Sports Exerc. 2010 Nov 11. [Epub ahead of print]
Antioxidant Supplementation Reduces Skeletal Muscle Mitochondrial Biogenesis.

Strobel NA, Peake JM, Matsumoto A, Marsh SA, Coombes JS, Wadley GD.

1The University of Queensland, Exercise and Oxidative Stress Research Group, School of Human Movement Studies, St. Lucia, Queensland, Australia, 4072; 2Program in Nutrition and Exercise Physiology, Washington State University, Spokane, Washington, USA, 99210; 3Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia, 3010; 4Centre for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia, 3125.
Abstract

PURPOSE: Exercise increases the production of reactive oxygen species (ROS) in skeletal muscle and athletes often consume antioxidant supplements in the belief they will attenuate ROS related muscle damage and fatigue during exercise. However, exercise-induced ROS may regulate beneficial skeletal muscle adaptations, such as increased mitochondrial biogenesis. We therefore investigated the effects of long-term antioxidant supplementation with vitamin E and α-lipoic acid on changes in markers of mitochondrial biogenesis in the skeletal muscle of exercise-trained and sedentary rats.

METHODS: Male Wistar rats were divided into four groups: 1) sedentary control diet, 2) sedentary antioxidant diet, 3) exercise control diet and 4) exercise antioxidant diet. Animals ran on a treadmill four days/week at ~70% VO2max for up to 90 min/day for 14 weeks.

RESULTS: Consistent with augmentation of skeletal muscle mitochondrial biogenesis and antioxidant defenses, following training there were significant increases in PGC-1α mRNA and protein, COX IV and cytochrome C protein abundance, citrate synthase activity, Nfe2l2 and SOD2 protein (P<0.05). Antioxidant supplementation reduced PGC-1α mRNA, PGC-1α and COX IV protein, and citrate synthase enzyme activity (P<0.05) in both sedentary and exercise-trained rats.

CONCLUSION: Vitamin E and α-lipoic acid supplementation suppresses skeletal muscle mitochondrial biogenesis, regardless of training status.

PMID: 21085043 [PubMed - as supplied by publisher]​

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[EMZ]

מפתיע. מעניין אם זה נכון לעוד נוגדי חמצון.

 

[adimenia]

אכן מפתיע.

 

[EMZ]

5 גרם ויטמין C 😳

 

[Kman]

לא הבנתי מה כל כך כתבו במאמר. בשורה אחת מה הנוגדי חימצון עשו?

 

[EMZ]

סלחו לי על הסופר הקפצה. אך האם למישהו יש את המלא?