תזונה ותוספים Fructose and Galactose Enhance Post-Exercise Human Liver Glycogen Synthesis.

[Mike Bikov]

Med Sci Sports Exerc. 2011 Mar 10. [Epub ahead of print]
Fructose and Galactose Enhance Post-Exercise Human Liver Glycogen Synthesis.

Décombaz J, Jentjens R, Ith M, Scheurer E, Buehler T, Jeukendrup A, Boesch C.

1 Nestlé Research Center, Lausanne, Switzerland 2 Department of Clinical Research, University of Bern, Switzerland 3 School of Sport and Exercise Science, University of Birmingham, United Kingdom.
Abstract

PURPOSE: Both liver and muscle glycogen stores play a fundamental role in exercise and fatigue, but the effect of different carbohydrate (CHO) sources on liver glycogen synthesis in humans is unclear. The aim was to compare the effect of maltodextrin (MD) drinks containing galactose, fructose or glucose on post-exercise liver glycogen synthesis.

METHODS: In this double blind, triple cross-over, randomized clinical trial 10 well-trained male cyclists performed 3 experimental exercise sessions separated by at least 1 wk. After performing a standard exercise protocol to exhaustion, subjects ingested one of three 15% CHO solutions: FRU (MD+fructose 2:1), GAL (MD+galactose 2:1) or GLU (MD+glucose 2:1), each providing 69 g CHO·h during 6.5 h recovery. Liver glycogen changes were followed using C-magnetic resonance spectroscopy.

RESULTS: Liver glycogen concentration increased at faster rates with FRU (24 ± 2 mmol·L·h; P <0.001) and with GAL (28 ± 3 mmol·L·h; P <0.001) than with GLU (13 ± 2 mmol·L·h). Liver volumes increased (P <0.001) with FRU (9 ± 2 %) and with GAL (10 ± 2 %), but not with GLU (2 ± 1 %, NS). Net glycogen synthesis appeared linear and was faster with FRU (8.1 ± 0.6 g·h; P <0.001) and with GAL (8.6 ± 0.9 g·h; P <0.001) than with GLU (3.7 ± 0.5 g·h)

CONCLUSION: When ingested at a rate designed to saturate intestinal CHO transport systems, MD drinks with added fructose or galactose were twice as effective as MD+glucose in restoring liver glycogen during short-term post-exercise recovery.

PMID: 21407126 [PubMed - as supplied by publisher]​

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