תזונה ותוספים Fasting Insulin Reflects Heterogeneous Physiologic Processes: Role of Insulin Clearan

[Mike Bikov]

Am J Physiol Endocrinol Metab. 2011 May 31. [Epub ahead of print]
Fasting Insulin Reflects Heterogeneous Physiologic Processes: Role of Insulin Clearance.
Goodarzi MO, Cui J, Chen YD, Hsueh WA, Guo X, Rotter JI.
Source

1Cedars-Sinai Medical Center.
Abstract

Several processes contribute to variation in fasting insulin concentration, including fasting glucose, insulin resistance, insulin secretion, and insulin clearance. Our goal was to determine the relative contribution of each of these insulin-related traits, plus anthropometric parameters, to fasting insulin among 470 Mexican Americans. The euglycemic hyperinsulinemic clamp yielded insulin sensitivity (M value) and metabolic clearance rate of insulin (MCRI). Acute insulin secretion was estimated by the insulinogenic index (IGI30) from the oral glucose tolerance test. Regression (univariate) and generalized estimating equations (multivariate) were used to describe the relationship of insulin-related traits to fasting insulin. Univarate analyses were used to select which traits to include in the multivariate model. In multivariate analysis, MCRI, M, body mass index, waist circumference, and fasting glucose were independently associated with fasting insulin. Decreasing M and MCRI were associated with increasing fasting insulin, while increasing body mass index (BMI), waist circumference and fasting glucose were associated with increasing fasting insulin. Standardized coefficients allowed determination of the relative strength of each trait's association with fasting insulin in the entire cohort (strongest to weakest): MCRI (-0.35, P<0.0001), M (-0.24, P<0.0001), BMI (0.20, P=0.0011), waist circumference (0.16, P=0.021), and fasting glucose (0.11, P=0.014). Fasting insulin is a complex phenotype influenced by several independent processes, each of which might have its own environmental and genetic determinants. One of the most associated traits was insulin clearance, which has implications for studies that have used fasting insulin as a surrogate for insulin resistance.

PMID:
21632466
[PubMed - as supplied by publisher]​

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