GLP-1 and energy balance: an integrated model of short-term and long-term control.

[Mike Bikov]

Nat Rev Endocrinol. 2011 Jun 7. [Epub ahead of print]
GLP-1 and energy balance: an integrated model of short-term and long-term control.
Barrera JG, Sandoval DA, D'Alessio DA, Seeley RJ.
Source

Department of Internal Medicine, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA.
Abstract

Glucagon-like peptide 1 (GLP-1), a peptide secreted from the intestine in response to nutrient ingestion, is perhaps best known for its effect on glucose-stimulated insulin secretion. GLP-1 is also secreted from neurons in the caudal brainstem, and it is well-established that, in rodents, central administration of GLP-1 potently reduces food intake. Over the past decade, GLP-1 has emerged not only as an essential component of the system that regulates blood glucose levels but also as a viable therapeutic target for the treatment of type 2 diabetes mellitus. However, although GLP-1 receptor agonists are known to produce modest but statistically significant weight loss in patients with diabetes mellitus, our knowledge of how endogenous GLP-1 regulates food intake and body weight remains limited. The purpose of this Review is to discuss the evolution of our understanding of how endogenous GLP-1 modulates energy balance. Specifically, we consider contributions of both central and peripheral GLP-1 and propose an integrated model of short-term and long-term control of energy balance. Finally, we discuss this model with respect to current GLP-1-based therapies and suggest ongoing research in order to maximize the effectiveness of GLP-1-based treatment of obesity.

PMID:
21647189
[PubMed - as supplied by publisher]​

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