Exercise and severe depression: Preliminary results of an add-on study.

[Mike Bikov]

J Affect Disord. 2011 May 24. [Epub ahead of print]
Exercise and severe depression: Preliminary results of an add-on study.
Schuch FB, Vasconcelos-Moreno MP, Borowsky C, Fleck MP.
Source

Hospital de Clínicas de Porto Alegre, Brazil; Programa de Pós-Graduação em ciências médicas: Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Abstract
BACKGROUND:

Physical exercise has been extensively researched as a therapeutic option for treatment of major depression.
METHODS:

In a randomized controlled trial, we analyze the effects of aerobic physical exercise as an add-on strategy for treatment of severe depressed inpatients. The exercise has a "Dose" of 16.5kcal/kg/week, three times a week during all the hospitalization.
RESULTS:

Our preliminary results show that there is no significant difference in scores of Hamilton in the second week between groups (Mean[SD]=8.2[5.96]×11.18[5.03], p=0.192). However, there is a significant reduction in Hamilton scores of patients in exercise group at discharge (Mean[SD]=5.93[4.46]×9.45[3.56], p=0.041). Regarding Quality of Life (QoL), no significant difference were found between groups in the second week in physical domain (Mean[SD]=56.98[8.96]×54.54[9.18], p=0.511) and psychological domain (Mean[SD]=50.88[13.88]×42.04[12.42], p=0.106). However, there is a significant difference in psychological domain (Mean[SD]=55.88[9.92] v 41.66[13.04], p=0.004) and a trend but no statistical significance in the physical (Mean[SD]=58.80[9.14]×52.12[8.70], p=0.07) at discharge.
LIMITATIONS:

Many patients receive different treatment strategies, like ECT (1 patient at exercise group×3 at control group). Other limitation is the small number of participants included until this moment.
CONCLUSION:

Our preliminary results suggest that physical exercise could be a feasible and effective add-on strategy for treatment of severe depressed inpatients, improving their depressive symptoms and QoL.​

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