תזונה ותוספים Evaluation of an oral standardized supplementation using 100,000IU vials of cholecalc

[Mike Bikov]

Joint Bone Spine. 2011 Nov 4. [Epub ahead of print]

Vitamin D insufficiency: Evaluation of an oral standardized supplementation using 100,000IU vials of cholecalciferol, depending on initial serum level of 25OH vitamin D.

Rouillon V, Dubourg G, Gauvain JB, Baron D, Glemarec J, Cormier G, Guillot P.

Source
Service de rhumatologie, centre hospitalier, BP 30071, 95503 Gonesse cedex, France.

Abstract

OBJECTIVES:
There is no protocol of vitamin D supplementation used worldwide due to a great disparity of vitamin D supplements available in different countries. The aim of this study was to evaluate the efficiency of the protocol most often used in France to correct vitamin D deficiency defined by a serum 25-hydroxy vitamin D (25OHD) level of less than 30ng/mL.

METHODS:
This was a pragmatic multicentric study of vitamin D supplementation in 257 osteopenic/osteoporotic, vitamin D deficient patients who received 100,000UI vitamin D3 vials every two weeks according to their initial serum 25OHD level (four vials when 25OHD less than 10ng/mL, three when 25OHD was 10-19ng/mL, two when 25OHD was 20-29ng/mL). Blood samples were obtained at baseline, one (M1), two (M2), and three months (M3), after the end of the supplementation protocol.

RESULTS:
At M1, 198/257 (77%) patients had a serum 25OHD level more than 30ng/mL. Eighty-five percent of those with a BMI less than 25kg/m(2) had a 25OHD concentration more than 30ng/mL, whereas only 66% of those with a BMI more than 25 had a level more than 30ng/mL. At M2 and M3, 25OHD levels decreased significantly with 55% and 46% having still a level more than 30ng/mL respectively, without any significant difference according to the initial 25OHD level.

CONCLUSION:
This protocol was effective in rising serum 25OHD of most vitamin D insufficient patients with a BMI less than 25kg/m(2), but not in overweight patients. As almost one half of our patients had a serum 25OHD level less than 30ng/mL at M2, we suggest that regular doses should be started quite soon after this initial supplementation.

Copyright © 2011 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.​

מעניין באיזו תצורה לקחו במחקר 100,000 יחידות של ויטמין D במכה.

 

[EMZ]

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