תזונה ותוספים Fine-tuning metabolism - how products of contraction regulate skeletal muscle adaptat

[Mike Bikov]

Am J Physiol Endocrinol Metab. 2012 Mar 20. [Epub ahead of print]
Fine-tuning metabolism - how products of contraction regulate skeletal muscle adaptation.
Philp A, Baar K.
Source

1University of California, Davis.
Abstract

With the emergence of molecular physiology (a synergy between classical physiology, biology, biochemistry, and molecular biology) research in the past decade has established that in addition to acting as substrates, metabolic intermediates also function as adaptive signals in skeletal muscle. These cellular signals now appear to be pivotal in mediating the adaptive response to exercise, above and beyond their role in the disposal of substrates. From a mechanistic perspective, it is logical that products of contraction feedback to 1) regulate their production, 2) affect their utilization, and 3) initiate changes in substrate selection. In light of this newfound appreciation of contraction derived intermediates, we are pleased to introduce this highlighted review series titled 'Intracellular signals for skeletal muscle adaptation'. The aim of this series, three reviews in each of the next three issues of the journal, is to provide a current viewpoint as to how metabolic intermediates may mediate adaptation in skeletal muscle.​

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