תזונה ותוספים Mechanisms of itch evoked by β-alanine.

[Mike Bikov]

J Neurosci. 2012 Oct 17;32(42):14532-7. doi: 10.1523/JNEUROSCI.3509-12.2012.
Mechanisms of itch evoked by β-alanine.

Liu Q, Sikand P, Ma C, Tang Z, Han L, Li Z, Sun S, LaMotte RH, Dong X.

Source
The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Abstract
β-Alanine, a popular supplement for muscle building, induces itch and tingling after consumption, but the underlying molecular and neural mechanisms are obscure. Here we show that, in mice, β-alanine elicited itch-associated behavior that requires MrgprD, a G-protein-coupled receptor expressed by a subpopulation of primary sensory neurons. These neurons exclusively innervate the skin, respond to β-alanine, heat, and mechanical noxious stimuli but do not respond to histamine. In humans, intradermally injected β-alanine induced itch but neither wheal nor flare, suggesting that the itch was not mediated by histamine. Thus, the primary sensory neurons responsive to β-alanine are likely part of a histamine-independent itch neural circuit and a target for treating clinical itch that is unrelieved by anti-histamines.

PMID: 23077038 [PubMed - indexed for MEDLINE] PMCID: PMC3491570 [Available on 2013/4/17]​

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