נק' מוניטין:
58,705
J Clin Endocrinol Metab. 2013 Dec 10:jc20133046. [Epub ahead of print]
Recovery of Endocrine and Inflammatory Mediators Following an Extended Energy Deficit.
Henning PC1, Scofield DE, Spiering BA, Staab JS, Matheny RW Jr, Smith MA, Bhasin S, Nindl BC.
Author information
Abstract
Context: Given the current operational needs, elite soldiers deploy quickly after completing arduous training courses, thus it is imperative that endocrine and inflammatory mediators have recovered. Objective: Determine whether a short-term (2-6 week) recovery period was sufficient to restore endocrine and inflammatory homeostasis following sustained energy deficit. Design: Before and immediately after the course, serum concentrations of inflammatory and endocrine markers were taken along with anthropometric measures. Additionally, nine soldiers were assessed between 2-6 weeks after the course. Setting: An intensive 8-wk military training course characterized by high energy expenditure, energy restriction, and sleep deprivation in a field setting (U.S. Army Ranger School). Participants: 23 male Soldiers (23.0 ± 2.8 y; 177.6 ± 7.9 cm; 81.0 ± 9.6 kg, 16.8 ± 3.9% body fat) participated. Interventions: No interventions were used. Outcome Measures and Results: Significant changes occurred in circulating total testosterone (-70%), BDNF (-33%), total IGF-1 (-41%), free IGF-1 (-44%), IGFBP-6 (-22%), sex-hormone binding globulin (+46%), thyroid stimulating hormone (+85%), IGFBP-1 (+272%), IGFBP-2 (+98%), IGFBP-3 (+20%), IL-4 (+87%), IL-6 (+169%) and IL-8 (+56%). Significant changes in body mass (-8%), bicep (-14%), forearm (-5%), thigh (-7%), and calf (-2%) circumferences, sum of skinfolds (-58%) and percent body fat (-58%). All anthropometric, inflammatory and hormonal values, except T3, were restored to baseline levels within 2-6 weeks after the course. Conclusions: Endocrine markers and anthropometric measures were degraded, and inflammatory mediators increased after an extended energy deficit. A short-term recovery of 2-6 weeks was sufficient to restore these mediators.
Recovery of Endocrine and Inflammatory Mediators Following an Extended Energy Deficit.
Henning PC1, Scofield DE, Spiering BA, Staab JS, Matheny RW Jr, Smith MA, Bhasin S, Nindl BC.
Author information
Abstract
Context: Given the current operational needs, elite soldiers deploy quickly after completing arduous training courses, thus it is imperative that endocrine and inflammatory mediators have recovered. Objective: Determine whether a short-term (2-6 week) recovery period was sufficient to restore endocrine and inflammatory homeostasis following sustained energy deficit. Design: Before and immediately after the course, serum concentrations of inflammatory and endocrine markers were taken along with anthropometric measures. Additionally, nine soldiers were assessed between 2-6 weeks after the course. Setting: An intensive 8-wk military training course characterized by high energy expenditure, energy restriction, and sleep deprivation in a field setting (U.S. Army Ranger School). Participants: 23 male Soldiers (23.0 ± 2.8 y; 177.6 ± 7.9 cm; 81.0 ± 9.6 kg, 16.8 ± 3.9% body fat) participated. Interventions: No interventions were used. Outcome Measures and Results: Significant changes occurred in circulating total testosterone (-70%), BDNF (-33%), total IGF-1 (-41%), free IGF-1 (-44%), IGFBP-6 (-22%), sex-hormone binding globulin (+46%), thyroid stimulating hormone (+85%), IGFBP-1 (+272%), IGFBP-2 (+98%), IGFBP-3 (+20%), IL-4 (+87%), IL-6 (+169%) and IL-8 (+56%). Significant changes in body mass (-8%), bicep (-14%), forearm (-5%), thigh (-7%), and calf (-2%) circumferences, sum of skinfolds (-58%) and percent body fat (-58%). All anthropometric, inflammatory and hormonal values, except T3, were restored to baseline levels within 2-6 weeks after the course. Conclusions: Endocrine markers and anthropometric measures were degraded, and inflammatory mediators increased after an extended energy deficit. A short-term recovery of 2-6 weeks was sufficient to restore these mediators.
