נק' מוניטין:
58,701
Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism
Hyeong-Kyu Park, Rexford S. Ahimaemail
Received: May 14, 2014; Received in revised form: August 1, 2014; Accepted: August 8, 2014; Published Online: August 15, 2014
DOI: http://dx.doi.org/10.1016/j.metabol.2014.08.004
Abstract
Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues. Leptin administration has been shown to restore metabolic and neuroendocrine abnormalities in individuals with leptin-deficient states, including hypothalamic amenorrhea and lipoatrophy. In contrast, obese individuals are resistant to leptin. Recombinant leptin is beneficial in patients with congenital leptin deficiency or generalized lipodystrophy. However, further research on molecular mediators of leptin resistance is needed for the development of targeted leptin sensitizing therapies for obesity and related metabolic diseases.
Hyeong-Kyu Park, Rexford S. Ahimaemail
Received: May 14, 2014; Received in revised form: August 1, 2014; Accepted: August 8, 2014; Published Online: August 15, 2014
DOI: http://dx.doi.org/10.1016/j.metabol.2014.08.004
Abstract
Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues. Leptin administration has been shown to restore metabolic and neuroendocrine abnormalities in individuals with leptin-deficient states, including hypothalamic amenorrhea and lipoatrophy. In contrast, obese individuals are resistant to leptin. Recombinant leptin is beneficial in patients with congenital leptin deficiency or generalized lipodystrophy. However, further research on molecular mediators of leptin resistance is needed for the development of targeted leptin sensitizing therapies for obesity and related metabolic diseases.
