ייעוץ סינפרין

[nir_abr]

שלום,
האם למישהו יש מידע לגבי החומר סינפרין? האם זה באמת עובד?
האם גם החומר הזה לא מומלץ לשימוש יחד עם יהומבין?

תודה.

 

[Mike Bikov]

Synephrine הוא אלפא 1 אגוניסט המכניזם שלו שונה מאפדרין.

יש את הנייר הבא שמראה שבמינונים גבוהים אכן יש משהו, כמו כן הוא עובד על הלפטין מה שיכול אולי לדכא רעב

***
Exp Biol Med (Maywood). 2004 Sep;229(8):698-704. Related Articles, Links

Comment in:

* Exp Biol Med (Maywood). 2004 Sep;229(8):695-7.
* Exp Biol Med (Maywood). 2005 Feb;230(2):102; discussion 103.


Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research.

Fugh-Berman A, Myers A.

Department of Physiology & Biophysics, Georgetown University, Box 571460, Washington, District of Columbia 20057-1460, USA. [email protected]

Seville orange (Citrus aurantium) extracts are being marketed as a safe alternative to ephedra in herbal weight-loss products, but C. aurantium may also have the potential to cause adverse health effects. C. aurantium contains synephrine (oxedrine), which is structurally similar to epinephrine. Although no adverse events have been associated with ingestion of C. aurantium products thus far, synephrine increases blood pressure in humans and other species, and has the potential to increase cardiovascular events. Additionally, C. aurantium contains 6',7'-dihydroxybergamottin and bergapten, both of which inhibit cytochrome P450-3A, and would be expected to increase serum levels of many drugs. There is little evidence that products containing C. aurantium are an effective aid to weight loss. Synephrine has lipolytic effects in human fat cells only at high doses, and octopamine does not have lipolytic effects in human adipocytes.

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[roei]

סינפרין וקפאין עובדים די טוב ביחד, אבל בתור שורף שומן עדיף את האפדרין+קפאין.