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Cell. 2015 Mar 12;160(6):1222-32. doi: 10.1016/j.cell.2015.02.024. Epub 2015 Mar 5.
Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding.
Dietrich MO1, Zimmer MR2, Bober J3, Horvath TL4.
Author information
Highlights
• Agrp neuron activation leads to foraging and displacement behaviors
• Agrp neurons promote stereotypic behavioral responses
• Activation of Agrp neurons decreases anxiety levels
• Y5R signaling is necessary for Agrp neuron-mediated stereotypic behaviors
Abstract
The nervous system evolved to coordinate flexible goal-directed behaviors by integrating interoceptive and sensory information. Hypothalamic Agrp neurons are known to be crucial for feeding behavior. Here, however, we show that these neurons also orchestrate other complex behaviors in adult mice. Activation of Agrp neurons in the absence of food triggers foraging and repetitive behaviors, which are reverted by food consumption. These stereotypic behaviors that are triggered by Agrp neurons are coupled with decreased anxiety. NPY5 receptor signaling is necessary to mediate the repetitive behaviors after Agrp neuron activation while having minor effects on feeding. Thus, we have unmasked a functional role for Agrp neurons in controlling repetitive behaviors mediated, at least in part, by neuropeptidergic signaling. The findings reveal a new set of behaviors coupled to the energy homeostasis circuit and suggest potential therapeutic avenues for diseases with stereotypic behaviors. PAPERCLIP.
Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding.
Dietrich MO1, Zimmer MR2, Bober J3, Horvath TL4.
Author information
Highlights
• Agrp neuron activation leads to foraging and displacement behaviors
• Agrp neurons promote stereotypic behavioral responses
• Activation of Agrp neurons decreases anxiety levels
• Y5R signaling is necessary for Agrp neuron-mediated stereotypic behaviors
Abstract
The nervous system evolved to coordinate flexible goal-directed behaviors by integrating interoceptive and sensory information. Hypothalamic Agrp neurons are known to be crucial for feeding behavior. Here, however, we show that these neurons also orchestrate other complex behaviors in adult mice. Activation of Agrp neurons in the absence of food triggers foraging and repetitive behaviors, which are reverted by food consumption. These stereotypic behaviors that are triggered by Agrp neurons are coupled with decreased anxiety. NPY5 receptor signaling is necessary to mediate the repetitive behaviors after Agrp neuron activation while having minor effects on feeding. Thus, we have unmasked a functional role for Agrp neurons in controlling repetitive behaviors mediated, at least in part, by neuropeptidergic signaling. The findings reveal a new set of behaviors coupled to the energy homeostasis circuit and suggest potential therapeutic avenues for diseases with stereotypic behaviors. PAPERCLIP.
