תזונה ותוספים Timing of ibuprofen use and bone mineral density adaptations to exercise training.

[Mike Bikov]

J Bone Miner Res. 2010 Jan 14. [Epub ahead of print]
Timing of ibuprofen use and bone mineral density adaptations to exercise training.

Kohrt WM, Barry DW, Van Pelt RE, Jankowski CM, Wolfe P, Schwartz RS.

Department of Medicine, Division of Geriatric Medicine, University of Colorado Denver.

Prostaglandins (PGs) are essential signaling factors in bone mechanotransduction. In animals, inhibition of the enzyme responsible for PG synthesis (cyclo-oxygenase) by non-steroidal anti-inflammatory drugs (NSAIDs) blocks the bone formation response to loading when administered before, but not immediately after, loading. The aim of this proof-of-concept study was to determine whether the timing of NSAID use influences BMD adaptations to exercise in humans. Healthy, premenopausal women (n = 73) aged 21 to 40 years completed a supervised 9-month weight-bearing exercise training program. They were randomized to take 1) ibuprofen (400 mg) before exercise, placebo after (IBUP/PLAC); 2) placebo before, ibuprofen after (PLAC/IBUP); or 3) placebo before and after (PLAC/PLAC). Relative changes in hip and lumbar spine bone mineral density (BMD) from before to after exercise training were assessed using a Hologic Delphi-W DXA instrument. Because this was the first study to evaluate whether ibuprofen use affects skeletal adaptations to exercise, only women who were compliant to exercise were included in the primary analyses (IBUP/PLAC, n = 17; PLAC/PLAC, n = 23; PLAC/IBUP, n = 14). There was a significant effect of drug treatment, adjusted for baseline BMD, on the BMD response to exercise for regions of the hip (total, P < 0.001; neck, P = 0.026; trochanter, P = 0.040; shaft, P = 0.019), but not the spine (P = 0.242). The largest increases in BMD occurring in the group that took ibuprofen after exercise. Total hip BMD changes averaged -0.2 +/- 1.3%, 0.4 +/- 1.8%, and 2.1 +/- 1.7% in IBUP/PLAC, PLAC/PLAC, and PLAC/IBUP, respectively. This preliminary study suggests that taking NSAIDs after exercise enhances the adaptive response of BMD to exercise, whereas taking NSAIDs before may impair the adaptive response.​

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