תזונה ותוספים Individual saturated fatty acids are associated with different components of insulin

[Mike Bikov]

Int J Circumpolar Health. 2010 Aug 18. [Epub ahead of print]
Individual saturated fatty acids are associated with different components of insulin resistance and glucose metabolism: the GOCADAN study.

Ebbesson SO, Tejero ME, López-Alvarenga JC, Harris WS, Ebbesson LO, Devereux RB, Maccluer JW, Wenger C, Laston S, Fabsitz RR, Howard BV, Comuzzie AG.

GOCADAN Department, Norton Sound Health Corporation, Nome, Alaska 99762, USA. [email protected].
Abstract

Objectives. Type 2 diabetes and the consumption of saturated fatty acids (FAs) are on the rise among Alaska Inuits. This analysis, based on a cross-sectional study, explores the possible associations of saturated FA content in red blood cells (RBCs) and parameters of glucose metabolism in a sample of Alaska Natives. Study design and methods. The sample included 343 women and 282 men aged 35-74. Statistical analyses explored the associations of selected RBC (myristic, palmitic and stearic acids) FAs with fasting glucose (plasma), fasting insulin (plasma), 2h glucose (2-hour glucose tolerance test), 2h insulin and homeostasis model assessment (HOMA) index. The models included sex and glucose metabolism status as fixed factors and age, body mass index (BMI), waist circumference, physical activity (METS) and FA content in RBCs as covariates. Measures of insulin, glucose and HOMA index were used as dependent variables. Results. Myristic acid was positively associated with fasting insulin (beta=0.47, p<0.001), 2h insulin (beta=0.53, p=0.02) and HOMA index (beta=0.455, p<0.001). Palmitic acid was associated with 2h glucose (beta=2.3x10-2, p<0.001) and 2h insulin (beta=5.6x10-2, p=0.002) and stearic acid was associated with fasting glucose (beta=4.8x10-3, p=0.006). Conclusions. These results strongly support the hypothesis that saturated fatty acids are associated with insulin resistance and glucose intolerance and that saturated fatty acids are significant risk factors for type 2 diabetes.

PMID: 20719107 [PubMed - as supplied by publisher]​

שומן רווי גם אחראי להתחממות הגלובאליות ולכור האטומי באירן

 

[EMZ]

יש במלא תיאור המנגנון שזה קורה? למה דווקא רוויות?
יש התיחסות למצב נורמלי ולא לסכרת סוג 2?
(איך מתאים לי ללמוד באקדמיה באלסקה)