תזונה ותוספים Effects of meals rich in either monounsaturated or saturated fat on lipid concentrati

[Mike Bikov]

Am J Clin Nutr. 2011 Jan 5. [Epub ahead of print]
Effects of meals rich in either monounsaturated or saturated fat on lipid concentrations and on insulin secretion and action in subjects with high fasting triglyceride concentrations1,2.

Lopez S, Bermudez B, Ortega A, Varela LM, Pacheco YM, Villar J, Abia R, Muriana FJ.

Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, and the Unidad Clinico-Experimental de Riesgo Vascular, Instituto de Biomedicina de Sevilla, CSIC/Universidad de Sevilla/Hospitales Virgen del Rocio, Seville, Spain.
Abstract

BACKGROUND: The nature of dietary fats and fasting concentrations of triglycerides affects postprandial hypertriglyceridemia and glucose homeostasis.

OBJECTIVES: The objectives were to examine the effects of meals enriched in monounsaturated fatty acids (MUFAs) or saturated fatty acids (SFAs) on postprandial lipid, glucose, and insulin concentrations and to examine the extent of β cell function and insulin sensitivity in subjects with high fasting triglyceride concentrations.

DESIGN: Fourteen men with fasting hypertriglyceridemia and normal glucose tolerance were given meals (≈10 kcal/kg body wt) containing MUFAs, SFAs, or no fat. Blood samples were collected at baseline and hourly over 8 h for analysis.

RESULTS: The high-fat meals significantly increased postprandial concentrations of triglycerides, nonesterified fatty acids, and insulin and postprandial indexes of β cell function. However, postprandial indexes of insulin sensitivity decreased significantly. These effects were significantly attenuated with MUFAs relative to SFAs.

CONCLUSIONS: MUFAs postprandially buffered β cell hyperactivity and insulin intolerance relative to SFAs in subjects with high fasting triglyceride concentrations. These data suggest that, in contrast with SFAs, MUFA-based strategies may provide cardiovascular benefits to persons at risk by limiting lipid and insulin excursions and may contribute to optimal glycemic control after meal challenges.

PMID: 21209225 [PubMed - as supplied by publisher]

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