תזונה ותוספים Effects of 28 days of resistance exercise while consuming commercially available pre-

[Mike Bikov]

Effects of 28 days of resistance exercise while consuming commercially available pre- and post-workout supplements, NO-Shotgun and NO-Synthesize on body composition, muscle strength and mass, markers of protein synthesis, and clinical safety markers in males

Mike Spillane, Neil Schwarz, Sarah Leddy, Tracie Correa, Melodie Minter, Victoria Longoria and Darryn S Willoughby


Nutrition & Metabolism 2011, 8:78 doi:10.1186/1743-7075-8-78
Published: 3 November 2011
Abstract (provisional)

Purpose: The effects of 28 days of heavy resistance training while ingesting the pre- and post-workout supplements, NO-Shotgun(R) and NO-Synthesize(R) were determined on body composition, muscle strength and mass, markers of protein synthesis, and clinical safety markers. Methods: Nineteen non-resistance-trained males participated in a resistance training program 4 times/week for 28 days while either ingesting 27 g/day of carbohydrate (CARB) or NO-Shotgun(R) 30 min pre-exercise and 27 g/day of carbohydrate or NO- Synthesize(R) 30 min post-exercise (NOSS). Data were analyzed with separate 2 x 2 ANOVA (p < 0.05). Results: Total body mass was increased in both groups (p = 0.001), but not different between groups. Fat mass was unchanged with CARB, but NOSS decreased fat mass (p = 0.026). Both groups increased fat-free mass (p = 0.001); however, the increases were greater with NOSS (p = 0.023). NOSS underwent greater increases in upper-body (p = 0.023) and lower-body (p = 0.035) strength than CARB. Myofibrillar protein significantly increased in both groups (p = 0.041), with NOSS being greater than CARB (p = 0.049). All of the MHC isoforms were significantly increased in both groups; however, NOSS was greater than CARB for MHC 1 (p = 0.013) and MHC 2A (p = 0.046). All of the myogenic regulatory factors were significantly increased in both groups; however, NOSS was greater than CARB for Myo-D (p = 0.038) and MRF-4 (p = 0.001). For the whole blood and serum clinical chemistry markers, all variables remained within normal clinical ranges. Conclusions: Heavy resistance training for 28 days, with NO-Shotgun(R) and NO-Synthesize(R) ingested before and after exercise, respectively, significantly improved body composition and increased muscle mass and performance without abnormally impacting any of the clinical chemistry markers.

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http://www.nutritionandmetabolism.com/content/pdf/1743-7075-8-78.pdf

Competing interests
This study was supported by an independent research grant from VPX (Davie, FL)
awarded to Baylor University. DSW has previously served as a paid consultant for VPX;
however, he was not serving in this capacity during the time in which this study was being
conducted, and has no financial interests concerning the outcome of the investigation. The
authors declare that they have no competing interests.

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