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Effect of Dietary Protein Intake on Diet-Induced Thermogenesis During Overfeeding
Elizabeth Frost Baton Rouge Louisiana, Leanne Redman Baton Rouge Louisiana, George Bray Baton Rouge Louisiana
Background: High protein diets for weight loss are popular and data suggests protein-mediated effects on satiety and thermogenesis may be potential mechanisms. This study determined if a prolonged change in dietary protein intake during overfeeding can modify
the thermogenic response to a standard meal.
Methods: Sixteen healthy individuals were randomized to overfeeding diets containing low (5% energy, n=6), normal (15% energy, n=5), or high (25% energy, n=5) protein for 8 weeks while living on a metabolic ward. Diet-induced thermogenesis (DIT) was measured over 4 hours by indirect calorimetry following a standard meal (40% of energy, 15% protein) or a breakfast meal specific to the study diet measured by a portable metabolic cart or in a whole room calorimeter, respectively. The area under the curve (AUC) for energy expenditure (EE) and substrate oxidation and DIT as percent of total EE were calculated.
Results: As expected, the AUC for EE following the overfeeding breakfast specific to each study group was significantly associated
with grams of protein (r2=0.32, P=0.02) with the AUC EE significantly increased in the high protein diet versus the low protein diet (HP: 178578, LP: 77278, kcal, P=0.05). However, DIT in response to a standard meal with the 15% protein was not associated with prolonged exposure to high energy intake (r2=0.12, P=0.16).
Conclusions: DIT is related to dietary protein but prolonged exposure to high energy diets does not alter the thermogenic response to a standard meal suggesting the DIT is likely under acute regulation and not involved in adaptive thermogenesis.
Elizabeth Frost Baton Rouge Louisiana, Leanne Redman Baton Rouge Louisiana, George Bray Baton Rouge Louisiana
Background: High protein diets for weight loss are popular and data suggests protein-mediated effects on satiety and thermogenesis may be potential mechanisms. This study determined if a prolonged change in dietary protein intake during overfeeding can modify
the thermogenic response to a standard meal.
Methods: Sixteen healthy individuals were randomized to overfeeding diets containing low (5% energy, n=6), normal (15% energy, n=5), or high (25% energy, n=5) protein for 8 weeks while living on a metabolic ward. Diet-induced thermogenesis (DIT) was measured over 4 hours by indirect calorimetry following a standard meal (40% of energy, 15% protein) or a breakfast meal specific to the study diet measured by a portable metabolic cart or in a whole room calorimeter, respectively. The area under the curve (AUC) for energy expenditure (EE) and substrate oxidation and DIT as percent of total EE were calculated.
Results: As expected, the AUC for EE following the overfeeding breakfast specific to each study group was significantly associated
with grams of protein (r2=0.32, P=0.02) with the AUC EE significantly increased in the high protein diet versus the low protein diet (HP: 178578, LP: 77278, kcal, P=0.05). However, DIT in response to a standard meal with the 15% protein was not associated with prolonged exposure to high energy intake (r2=0.12, P=0.16).
Conclusions: DIT is related to dietary protein but prolonged exposure to high energy diets does not alter the thermogenic response to a standard meal suggesting the DIT is likely under acute regulation and not involved in adaptive thermogenesis.
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http://www.obesity.org/news-center/...e-trained-to-maintain-a-higher-metabolism.htm
