תזונה ותוספים Exercise-training versus diet-induced weight-loss on metabolic risk factors and infla

[Mike Bikov]

Am J Physiol Endocrinol Metab. 2010 Jan 19. [Epub ahead of print]
Exercise-training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects.A 12-week randomized intervention-study.

Christiansen T, Paulsen SK, Bruun JM, Pedersen SB, Richelsen B.

1Aarhus University Hospital.

The purpose of this study was to investigate the effect of exercise training and diet-induced weight loss alone or in combination on inflammatory markers in circulation, in adipose tissue (AT), and in skeletal muscle (SM) in obese subjects. 79 obese subjects were randomized into a 12-week intervention, 1) exercise-only (EXO), 2) diet-induced weight-loss using a very-low energy diet (DIO), and 3) exercise and diet-induced weight-loss combined (DEX). Blood-samples (metabolic and inflammatory markers) and AT and SM-biopsies (mRNA expression) were collected at baseline and after 12weeks. In the EXO-group the weight loss was 3.5 kg and in the DIO and DEX-groups it was 12 kg in both. VO2max was increased by 14-18% in the EXO and DEX-groups with no changes in the DIO group. In the DIO and DEX-groups circulating levels of MCP-1, MIP-1alpha, IL-15, and IL-18 were decreased and adiponectin was increased (p<0.05 for all). In the EXO-group MCP-1 was decreased with 10% (p=0.06). By combining the weight loss in all three groups we found a correlation between the degree of weight loss and improvement in several of the inflammatory markers (p<0.05). In AT-biopsies, subjects in the DIO and DEX-groups achieved a general beneficial but non-significant effect on the gene expression of inflammatory. In the EXO group no changes in AT adipokine mRNA were found except for an increment of adiponectin (p<0.05). In SM, the only observed change was that the gene expression of IL-6 was increased in all three groups (p<0.05). In conclusion, rather large weight losses (more than 5-7%) were found to have beneficial effects on circulating inflammatory markers in these obese subjects. Aerobic exercise for 12weeks which increased VO2max was found to have no effects on circulating inflammatory markers in these obese patients. It is suggested that more intensive exercise may be necessary to affect systemic inflammation.​

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