Anabolic and catabolic pathways regulating skeletal muscle mass

[Mike Bikov]

Curr Opin Clin Nutr Metab Care. 2010 Feb 11. [Epub ahead of print]

Anabolic and catabolic pathways regulating skeletal muscle mass.

McCarthy JJ, Esser KA.

Center for Muscle Biology, Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.

PURPOSE OF REVIEW: The purpose of this review is to discuss recent findings as they pertain to anabolic and catabolic-signaling pathways involved in the regulation of adult skeletal muscle mass. RECENT FINDINGS: Research conducted over the past few years has continued to refine our understanding of the pathways that govern skeletal muscle mass, in particular the mTOR, FoxO and NF-kappaB pathways. Alternative signaling pathways have also emerged as important regulators of muscle mass such as the beta-catenin pathway. SUMMARY: A better understanding of the anabolic and catabolic processes which regulate skeletal muscle mass is critical for the development of more effective therapeutics to prevent the loss of muscle with disuse, aging and disease.​

🤫