Cholesterol Lowering, Cardiovascular Diseases, and the JUPITER Controversy

[coldfire]

[FONT=verdana, arial, helvetica, sans-serif]Cholesterol Lowering, Cardiovascular Diseases, and the Rosuvastatin-JUPITER Controversy[/FONT][FONT=verdana, arial, helvetica, sans-serif]A Critical Reappraisal [/FONT]
[FONT=verdana, arial, helvetica, sans-serif] Michel de Lorgeril, MD; Patricia Salen, BSc; John Abramson, MD; Sylvie Dodin, MD; Tomohito Hamazaki, PhD; Willy Kostucki, MD; Harumi Okuyama, PhD; Bruno Pavy, MD; Mikael Rabaeus, MD [/FONT]

[FONT=verdana, arial, helvetica, sans-serif] Arch Intern Med. 2010;170(12):1032-1036. [/FONT]
[FONT=verdana, arial, helvetica, sans-serif] Background Among the recently reported cholesterol-lowering drug trials, the JUPITER (Justification for the Use of Statins in Primary Prevention) trial is unique: it reports a substantial decrease in the risk of cardiovascular diseases among patients without coronary heart disease and with normal or low cholesterol levels. [/FONT]
[FONT=verdana, arial, helvetica, sans-serif]Methods Careful review of both results and methods used in the trial and comparison with expected data. [/FONT]
[FONT=verdana, arial, helvetica, sans-serif]Results The trial was flawed. It was discontinued (according to prespecified rules) after fewer than 2 years of follow-up, with no differences between the 2 groups on the most objective criteria. Clinical data showed a major discrepancy between significant reduction of nonfatal stroke and myocardial infarction but no effect on mortality from stroke and myocardial infarction. Cardiovascular mortality was surprisingly low compared with total mortality—between 5% and 18%—whereas the expected rate would have been close to 40%. Finally, there was a very low case-fatality rate of myocardial infarction, far from the expected number of close to 50%. The possibility that bias entered the trial is particularly concerning because of the strong commercial interest in the study. [/FONT]
[FONT=verdana, arial, helvetica, sans-serif]Conclusion The results of the trial do not support the use of statin treatment for primary prevention of cardiovascular diseases and raise troubling questions concerning the role of commercial sponsors.[/FONT]
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סטטינים זה נפלא 🤘

הקובץ מצורף

 

[Mike Bikov]

אבל צור קסטל אמר...

 

[bentzurm]

JUPITER זה בזיון ואולי הדוגמה המוחשית ביותר לסכנות שבמחקר מנוהל וממומן על ידי חברות התרופות.

 

[מר לטיסימוס]

אתם לא מבינים כלום. אחרי שאתם תמותו מהתקף לב שנגרם מכולסטרול, אולי גם אתם תתחילו לקחת סטטינים.

 

[coldfire]

רגע, אז איך זה מרגיש למות?

 

[מר לטיסימוס]

רגע, אז איך זה מרגיש למות?

תשאל את פרופסור קרסו.

 

[asdasd]

רגע, אז איך זה מרגיש למות?

בערך כמו שמרגיש לקבל איידס מתת תזונה, רק קצת יותר מציאותי.

 

[coldfire]

בערך כמו שמרגיש לקבל איידס מתת תזונה, רק קצת יותר מציאותי.

AIDS researchers in Africa, including those from the CDC and WHO, admit that immune deficiency in Africa has existed for a considerable time and this has not been due to HIV. "Tuberculosis, protein calorie malnutrition, and various parasitic diseases can all be associated with depression of cellular immunity" (Piot et al., 1984). "

 

[asdasd]

AIDS researchers in Africa, including those from the CDC and WHO, admit that immune deficiency in Africa has existed for a considerable time and this has not been due to HIV. "Tuberculosis, protein calorie malnutrition, and various parasitic diseases can all be associated with depression of cellular immunity" (Piot et al., 1984). "

Fredd Bear's Breakfast A-Go-Go was an award winning Australian children's television show which started in 1969 on ATV Channel 0 (now ATV-10).
Running five days a week (Monday to Friday from 7am) for three years, with a mixture of cartoons, serials, music clips, news, and entertainment, it was comparable to an early Hey Hey It's Saturday.
The show was hosted by Fredd Bear (Tedd Dunn), a lively non-speaking character first seen on the Magic Circle Club, and Judy Banks. Regulars included Colin McEwan, newsreader Michael McCarthy and magician Ian Buckland. Bruce Rowland was the musical director and wrote the theme tune. In 1975, Tedd Dunn won a Logie Award for Outstanding Creative Effort for his work on the program.[1]
A membership card system was one of the methods by which the show's young audience was encouraged to stay viewing. At intervals of approximately 10-15 minutes, a viewer's membership card number would be superimposed on the screen, entitling the viewer to a prize if they contacted the station.
Since each day's show was videotaped purely for reference purposes and not archived, with the same tape reused every day, almost none of the show remains in existence. The only footage from Fredd Bear's Breakfast-A-Go-Go believed to exist is a performance by former Seekers member Bruce Woodley of his advertising jingle The ANZ Bank Travelling Man.
The album Judy Banks - A Paw Full of Songs was produced by her husband Bob Phillips and released in 1972.
In 1969, Sydney's Good Morning!!! breakfast show on TEN-10 was renamed Breakfast-a-Go-Go, bringing it into line with Melbourne's Fredd Bear's Breakfast-A-Go-Go.

 

[DMDaniel]

בערך כמו שמרגיש לקבל איידס מתת תזונה, רק קצת יותר מציאותי.

LOL.