תזונה ותוספים Endurance exercise training blunts the deleterious effect of high-fat feeding on whol

[Mike Bikov]

Am J Physiol Regul Integr Comp Physiol. 2011 Jun 1. [Epub ahead of print]
Endurance exercise training blunts the deleterious effect of high-fat feeding on whole-body efficiency.
Edwards LM, Holloway CJ, Murray AJ, Knight NS, Carter EE, Kemp GJ, Thompson CH, Tyler DJ, Neubauer S, Robbins PA, Clarke K.
Source

1University of Tasmania.
Abstract

We recently showed that a week-long high-fat diet reduced whole-body exercise efficiency in sedentary men by > 10%. To test if a similar dietary regime would blunt whole-body efficiency in trained men and, as a consequence, hinder aerobic exercise performance, sixteen trained men were given a short-term high fat (70% kcal from fat) and a moderate carbohydrate (50% kcal from carbohydrate) diet (MCD), in random order. Efficiency was assessed during a standardised exercise task on a cycle ergometer, with aerobic performance assessed during a one-hour time trial and mitochondrial function later measured using (31)P-magnetic resonance spectroscopy. The subjects then underwent a two-week wash-out period, before the study was repeated with the diets crossed-over. Muscle biopsies, for mitochondrial protein analysis, were taken at the start of the study and on the fifth day of each diet. Plasma fatty acids were 60% higher on the high-fat diet (HFD) compared with MCD (p < 0.05). However, there was no change in whole-body efficiency and no change in mitochondrial function. Endurance exercise performance was significantly reduced (p < 0.01), most probably due to glycogen depletion. Neither diet led to changes in citrate synthase, ATP-synthase or the mitochondrial uncoupling protein (UCP3). We conclude that prior exercise training blunts the deleterious effect of short-term high-fat feeding on whole-body efficiency.

PMID:
21632846
[PubMed - as supplied by publisher]​

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