אימונים Is sprint exercise a leptin signaling mimetic in human skeletal muscle?

[Mike Bikov]

J Appl Physiol. 2011 Jun 9. [Epub ahead of print]
Is sprint exercise a leptin signaling mimetic in human skeletal muscle?
Guerra B, Olmedillas H, Guadalupe-Grau A, Ponce-Gonzalez JG, Morales-Alamo D, Fuentes T, Chapinal E, Fernandez-Perez L, De Pablos-Velasco P, Santana A, Calbet JA.
Source

1University of Las Palmas de Gran Canaria.
Abstract

This study was designed to determine whether sprint exercise activates signaling cascades linked to leptin actions in human skeletal muscle and how this pattern of activation may be interfered by glucose ingestion. Muscle biopsies were obtained in fifteen young healthy men in response to a 30 s sprint exercise (Wingate test) randomly distributed into two groups: the fasting (n=7, C), and the glucose group (n=8, G), who ingested 75g of glucose one hour before the Wingate test. Exercise elicited different patterns of JAK2, STAT3, STAT5, ERK1/2, p38 MAPK phosphorylation and SOCS3 protein expression, during the recovery period after glucose ingestion. Thirty min after the control sprint STAT3 and ERK1/2 phosphorylation levels were augmented (both, P<0.05). SOCS3 protein expression was increased 120 min after the control sprint but PTP1B protein expression was unaffected. Thirty and 120 min after the control sprint STAT5 phosphorylation was augmented (P<0.05). Glucose abolished the 30 min STAT3 and ERK1/2 phosphorylation and the 120 min SOCS3 protein expression increase , while retarding the STAT5 phosphorylation response to sprint. Activation of these signaling cascades occurred despite a reduction of circulating leptin concentration after the sprint. Basal JAK2 and p38 MAPK phosphorylation levels were reduced and increased (both P<0.05), respectively, by glucose ingestion prior to exercise. During recovery JAK2 phosphorylation was unchanged and p38 MAPK phosphorylation was transiently reduced, when the exercise was preceded by glucose ingestion. . In conclusion, sprint exercise performed under fasting conditions is a leptin signaling mimetic in human skeletal muscle.​

;susss;susss

 

[Wonder Land]

אז לא בדיוק הבנתי... כאשר אני מבצע ספרינט בצום אז יש אות נמוך ללפטין?
לאחר שאכלתי "גלוקוז" מה בדיוק זה יתן לי האות המוגבר הזה ללפטין? ז"א מה היתרון הזה בדיוק?

 

[Mike Bikov]

אז לא בדיוק הבנתי... כאשר אני מבצע ספרינט בצום אז יש אות נמוך ללפטין?
לאחר שאכלתי "גלוקוז" מה בדיוק זה יתן לי האות המוגבר הזה ללפטין? ז"א מה היתרון הזה בדיוק?

רמות גבוהות של לפטין = רעב מוגבר + רמות קורטיזול גבוהות. וההפך.