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Mol Cell Endocrinol. 2009 Aug 21. [Epub ahead of print]Click here to read Links
Stranger in a Strange Land: Roles of Glycogen Turnover in Adipose Tissue Metabolism.
Markan KR, Jurczak MJ, Brady MJ.
Department of Medicine, Section of Endocrinology, Diabetes and Metabolism and the Committee on Molecular Metabolism and Nutrition, 5841 South Maryland Avenue, The University of Chicago, Chicago, Illinois 60637, USA.
Triglyceride storage in adipose tissue comprises the principal energy reserve in mammals. Additionally glucose can be stored as glycogen in the fed state, primarily in liver and skeletal muscle, for mobilization during times of energy deficit. Adipose tissue also contains glycogen stores albeit at very low levels. The physiological role of glycogen metabolism in adipocytes remains unclear. However, both classical literature and more recent work demonstrate that the dynamic regulation of adipose glycogen may serve as an energy sensing modality in the coordination of glucose and lipid metabolism in adipose tissue, especially during the fasted to fed transition.
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