Expression of human chemerin induces insulin resistance in the skeletal muscle but do

[Mike Bikov]

Diabetes. 2010 Aug 19. [Epub ahead of print]
Expression of human chemerin induces insulin resistance in the skeletal muscle but does not affect weight, lipid levels and atherosclerosis in LDL receptor knockout mice on high fat diet.

Becker M, Rabe K, Lebherz C, Zugwurst J, Göke B, Parhofer KG, Lehrke M, Broedl UC.

Department of Internal Medicine II, University of Munich, Munich, Germany.
Abstract

AbstractObjective. Chemerin is a recently discovered hepatoadipokine that regulates adipocyte differentiation as well as chemotaxis and activation of dendritic cells and macrophages. Chemerin was reported to modulate insulin sensitivity in adipocytes and skeletal muscle cells in vitro and to exacerbate glucose intolerance in several mouse models in vivo. In humans, chemerin was shown to be associated with multiple components of the metabolic syndrome including body mass index, triglycerides, HDL-cholesterol and hypertension. This study was aimed to examine the effect of chemerin on weight, glucose and lipid metabolism as well as atherosclerosis in vivo. Research Design and Methods. We used recombinant adeno-associated virus to express human chemerin in LDL receptor knockout mice on high fat diet. Results. Expression of chemerin did not significantly alter weight, lipid levels, and extent of atherosclerosis. Chemerin, however, significantly increased glucose levels during the intraperitoneal glucose tolerance test without affecting endogenous insulin levels and the insulin tolerance test. Chemerin reduced insulin-stimulated Akt1 phosphorylation and activation of 5'AMP activated protein kinase (AMPK) in the skeletal muscle, but had no effect on Akt phosphorylation and insulin-stimulated AMPK activation in the liver and gonadal adipose tissue. Conclusions. Chemerin induces insulin resistance in the skeletal muscle in vivo. Chemerin is involved in the cross talk between liver, adipose tissue and skeletal muscle.

PMID: 20724582 [PubMed - as supplied by publisher]​

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