תזונה ותוספים Fatty acid flux in adipocytes; the in's and out ’s of fat cell lipid trafficking

[Mike Bikov]

Molecular and Cellular Endocrinology, Article in Press

Fatty acid flux in adipocytes; the in's and out ’s of fat cell lipid trafficking
Brian R. Thompson, a, , Sandra Loboa and David A. Bernlohra

aDepartment of Biochemistry, Molecular Biology and Biophysics, The University of Minnesota-Twin Cities Minneapolis, MN 55455

Received 10 July 2009; revised 19 August 2009; accepted 20 August 2009. Available online 29 August 2009.



The trafficking of fatty acids into and out of adipocytes is regulated by a complex series of proteins and enzymes and is under control by a variety of hormonal and metabolic factors. The biochemical basis of fatty acid influx, despite its widespread appreciation, remains enigmatic with regard to the biophysical and biochemical properties that facilitate long chain fatty acid uptake. Fatty acid efflux is initiated by hormonally controlled lipolysis of the droplet stores and produces fatty acids that must transit from their site of production to the plasma membrane and subsequently out of the cells. This review will focus on the “in ’s and out ’s” of fatty acid trafficking and summarize the current concepts in the field.

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