נק' מוניטין:
2,836
בוא נאמר שרב הסגולות הבריאותיות של קפה לא מחזיקות מעמד אחרי התהליך המתועש שלהם.
עכשיו, אם אתה מדבר על פולי קפה טריים זה כבר סיפור אחר.
אבל אם כבר אז תה ירוק (עדיף חליטה מעלים מיובשים, עולה גרושים בחנויות טבע, תבלינים וכו')
עכשיו, אם אתה מדבר על פולי קפה טריים זה כבר סיפור אחר.
אבל אם כבר אז תה ירוק (עדיף חליטה מעלים מיובשים, עולה גרושים בחנויות טבע, תבלינים וכו')
נק' מוניטין:
6,632
Coffee consumption and risk of type 2 diabetes mellitus.
van Dam RM, Feskens EJ.
Department of Chronic Diseases Epidemiology, National Institute for Public Health and the Environment, 3720 BA, Bilthoven, Netherlands. [email protected]
Coffee is a major source of caffeine, which has been shown to acutely reduce sensitivity to insulin, but also has potentially beneficial effects. We prospectively investigated the association between coffee consumption and risk of clinical type 2 diabetes in a population-based cohort of 17111 Dutch men and women aged 30-60 years. During 125774 person years of follow-up, 306 new cases of type 2 diabetes were reported. After adjustment for potential confounders, individuals who drank at least seven cups of coffee a day were 0.50 (95% CI 0.35-0.72, p=0.0002) times as likely as those who drank two cups or fewer a day to develop type 2 diabetes. Coffee consumption was associat
PMID: 12433517 [PubMed - indexed for MEDLINE]
Caffeinated coffee, decaffeinated coffee, and caffeine in relation to plasma C-peptide levels, a marker of insulin secretion, in U.S. women.
Wu T, Willett WC, Hankinson SE, Giovannucci E.
Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115, USA. [email protected]
OBJECTIVE: Coffee consumption is associated with reduced risk of type 2 diabetes, but the mechanism is not clearly understood. Elevated C-peptide, as a marker of insulin secretion, has been linked to insulin-resistant type 2 diabetes. In this study, we examined consumption of caffeinated and decaffeinated coffee and total caffeine in relation to concentrations of plasma C-peptide. RESEARCH DESIGN AND METHODS: Plasma C-peptide concentrations were measured in a cross-sectional setting among 2,112 healthy women from the Nurses' Health Study I who provided blood samples in 1989-1990. Consumption of caffeinated and decaffeinated coffee and total caffeine was assessed using a semiquantitative food-frequency questionnaire in 1990. RESULTS: Intakes of caffeinated and decaffeinated coffee and caffeine in 1990 were each inversely associated with C-peptide concentration in age-adjusted, BMI-adjusted, and multivariable-adjusted analyses. In multivariable analysis, concentrations of C-peptide were 16% less in women who drank >4 cups/day of caffeinated or decaffeinated coffee compared with nondrinkers (P < 0.005 for each). Women in the highest quintile compared with the lowest quintile of caffeine intake had 10% lower C-peptide levels (P = 0.02). We did not find any association between tea and C-peptide. The inverse association between caffeinated coffee and C-peptide was considerably stronger in obese (27% reduction) and overweight women (20% reduction) than in normal weight women (11% reduction) (P = 0.005). CONCLUSIONS: Our findings suggest a potential reduction of insulin secretion by coffee in women. This reduction may be related to other components in coffee rather than caffeine.
PMID: 15920057 [PubMed - indexed for MEDLINE]
Coffee, caffeine, and risk of type 2 diabetes: a prospective cohort study in younger and middle-aged U.S. women.
van Dam RM, Willett WC, Manson JE, Hu FB.
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115, USA. [email protected]
OBJECTIVE: High habitual coffee consumption has been associated with a lower risk of type 2 diabetes, but data on lower levels of consumption and on different types of coffee are sparse. RESEARCH DESIGN AND METHODS: This is a prospective cohort study including 88,259 U.S. women of the Nurses' Health Study II aged 26-46 years without history of diabetes at baseline. Consumption of coffee and other caffeine-containing foods and drinks was assessed in 1991, 1995, and 1999. We documented 1,263 incident cases of confirmed type 2 diabetes between 1991 and 2001. RESULTS: After adjustment for potential confounders, the relative risk of type 2 diabetes was 0.87 (95% CI 0.73-1.03) for one cup per day, 0.58 (0.49-0.68) for two to three cups per day, and 0.53 (0.41-0.68) for four or more cups per day compared with nondrinkers (P for trend <0.0001). Associations were similar for caffeinated (0.87 [0.83-0.91] for a one-cup increment per day) and decaffeinated (0.81 [0.73-0.90]) coffee and for filtered (0.86 [0.82-0.90]) and instant (0.83 [0.74-0.93]) coffee. Tea consumption was not substantially associated with risk of type 2 diabetes (0.88 [0.64-1.23] for four or more versus no cups per day; P for trend = 0.81). CONCLUSIONS: These results suggest that moderate consumption of both caffeinated and decaffeinated coffee may lower risk of type 2 diabetes in younger and middle-aged women. Coffee constituents other than caffeine may affect the development of type 2 diabetes.
Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions
The Glucose Intolerance Induced by Caffeinated Coffee Ingestion Is Less
Pronounced than That Due to Alkaloid Caffeine in Men1,2
Danielle S. Battram3, Rebecca Arthur, Andrew Weekes and Terry E. Graham
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
3 To whom correspondence should be addressed. E-mail: [email protected].
Although acute alkaloid caffeine (CAF) ingestion results in an impaired glucose tolerance, chronic coffee (RCOF) ingestion decreases the risk of developing type 2 diabetes. This study examines the hypothesis that CAF ingestion impairs glucose tolerance to a greater extent than RCOF and that the ingestion of decaffeinated coffee (DECAF) results in a positive effect. Eleven healthy males underwent 4 double-blinded randomized trials. Each trial included the ingestion of either: 1) CAF in capsule form (4.45 mg/kg body weight), 2) RCOF (4.45 mg/kg body weight caffeine), 3) dextrose (placebo, PL) in capsule form, or 4) DECAF (equal in volume to the RCOF trial), followed 1-h later by a 2-h oral glucose tolerance test. Blood samples were collected at baseline (–30), 0 (time of treatment ingestion), 60 (initiation of oral glucose tolerance test), 75, 90, 120, 150, and 180 min. Area under the curve for glucose and insulin were higher (P ≤ 0.05) following CAF than both PL and DECAF and, although a similar trend (P = 0.07) was observed following RCOF compared with DECAF, the effect was less pronounced. Interestingly, DECAF resulted in a 50% lower glucose response (P ≤ 0.05) than PL, suggesting that the effects of PL and DECAF on glucose tolerance are not the same. These findings suggest that the effects of CAF and RCOF are not identical and may provide a partial explanation as to why acute CAF ingestion impairs glucose tolerance while chronic RCOF ingestion protects against type 2 diabetes.
לסיכום:
צריכת קפה (לא קפאין) באופן כרוני משפרת את הרגישות לאינסולין ולכאורה מניעת סכרת מסוג II.
מדובר לא בקפאין אלה בחומרים אחרים שנמצאים בקפה כמו פוליפנולים, פיטוכמיקלים נוגדי חמצון (אנטי אוקסידנטים). צריכה בצורה סייקלסטית של קפאין יתן את אפקט המרץ ועירנות, תוריד את הרגישות לאנסולין, ותסייע לירידת/שמירת משקל.
van Dam RM, Feskens EJ.
Department of Chronic Diseases Epidemiology, National Institute for Public Health and the Environment, 3720 BA, Bilthoven, Netherlands. [email protected]
Coffee is a major source of caffeine, which has been shown to acutely reduce sensitivity to insulin, but also has potentially beneficial effects. We prospectively investigated the association between coffee consumption and risk of clinical type 2 diabetes in a population-based cohort of 17111 Dutch men and women aged 30-60 years. During 125774 person years of follow-up, 306 new cases of type 2 diabetes were reported. After adjustment for potential confounders, individuals who drank at least seven cups of coffee a day were 0.50 (95% CI 0.35-0.72, p=0.0002) times as likely as those who drank two cups or fewer a day to develop type 2 diabetes. Coffee consumption was associat
PMID: 12433517 [PubMed - indexed for MEDLINE]
Caffeinated coffee, decaffeinated coffee, and caffeine in relation to plasma C-peptide levels, a marker of insulin secretion, in U.S. women.
Wu T, Willett WC, Hankinson SE, Giovannucci E.
Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115, USA. [email protected]
OBJECTIVE: Coffee consumption is associated with reduced risk of type 2 diabetes, but the mechanism is not clearly understood. Elevated C-peptide, as a marker of insulin secretion, has been linked to insulin-resistant type 2 diabetes. In this study, we examined consumption of caffeinated and decaffeinated coffee and total caffeine in relation to concentrations of plasma C-peptide. RESEARCH DESIGN AND METHODS: Plasma C-peptide concentrations were measured in a cross-sectional setting among 2,112 healthy women from the Nurses' Health Study I who provided blood samples in 1989-1990. Consumption of caffeinated and decaffeinated coffee and total caffeine was assessed using a semiquantitative food-frequency questionnaire in 1990. RESULTS: Intakes of caffeinated and decaffeinated coffee and caffeine in 1990 were each inversely associated with C-peptide concentration in age-adjusted, BMI-adjusted, and multivariable-adjusted analyses. In multivariable analysis, concentrations of C-peptide were 16% less in women who drank >4 cups/day of caffeinated or decaffeinated coffee compared with nondrinkers (P < 0.005 for each). Women in the highest quintile compared with the lowest quintile of caffeine intake had 10% lower C-peptide levels (P = 0.02). We did not find any association between tea and C-peptide. The inverse association between caffeinated coffee and C-peptide was considerably stronger in obese (27% reduction) and overweight women (20% reduction) than in normal weight women (11% reduction) (P = 0.005). CONCLUSIONS: Our findings suggest a potential reduction of insulin secretion by coffee in women. This reduction may be related to other components in coffee rather than caffeine.
PMID: 15920057 [PubMed - indexed for MEDLINE]
Coffee, caffeine, and risk of type 2 diabetes: a prospective cohort study in younger and middle-aged U.S. women.
van Dam RM, Willett WC, Manson JE, Hu FB.
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115, USA. [email protected]
OBJECTIVE: High habitual coffee consumption has been associated with a lower risk of type 2 diabetes, but data on lower levels of consumption and on different types of coffee are sparse. RESEARCH DESIGN AND METHODS: This is a prospective cohort study including 88,259 U.S. women of the Nurses' Health Study II aged 26-46 years without history of diabetes at baseline. Consumption of coffee and other caffeine-containing foods and drinks was assessed in 1991, 1995, and 1999. We documented 1,263 incident cases of confirmed type 2 diabetes between 1991 and 2001. RESULTS: After adjustment for potential confounders, the relative risk of type 2 diabetes was 0.87 (95% CI 0.73-1.03) for one cup per day, 0.58 (0.49-0.68) for two to three cups per day, and 0.53 (0.41-0.68) for four or more cups per day compared with nondrinkers (P for trend <0.0001). Associations were similar for caffeinated (0.87 [0.83-0.91] for a one-cup increment per day) and decaffeinated (0.81 [0.73-0.90]) coffee and for filtered (0.86 [0.82-0.90]) and instant (0.83 [0.74-0.93]) coffee. Tea consumption was not substantially associated with risk of type 2 diabetes (0.88 [0.64-1.23] for four or more versus no cups per day; P for trend = 0.81). CONCLUSIONS: These results suggest that moderate consumption of both caffeinated and decaffeinated coffee may lower risk of type 2 diabetes in younger and middle-aged women. Coffee constituents other than caffeine may affect the development of type 2 diabetes.
Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions
The Glucose Intolerance Induced by Caffeinated Coffee Ingestion Is Less
Pronounced than That Due to Alkaloid Caffeine in Men1,2
Danielle S. Battram3, Rebecca Arthur, Andrew Weekes and Terry E. Graham
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
3 To whom correspondence should be addressed. E-mail: [email protected].
Although acute alkaloid caffeine (CAF) ingestion results in an impaired glucose tolerance, chronic coffee (RCOF) ingestion decreases the risk of developing type 2 diabetes. This study examines the hypothesis that CAF ingestion impairs glucose tolerance to a greater extent than RCOF and that the ingestion of decaffeinated coffee (DECAF) results in a positive effect. Eleven healthy males underwent 4 double-blinded randomized trials. Each trial included the ingestion of either: 1) CAF in capsule form (4.45 mg/kg body weight), 2) RCOF (4.45 mg/kg body weight caffeine), 3) dextrose (placebo, PL) in capsule form, or 4) DECAF (equal in volume to the RCOF trial), followed 1-h later by a 2-h oral glucose tolerance test. Blood samples were collected at baseline (–30), 0 (time of treatment ingestion), 60 (initiation of oral glucose tolerance test), 75, 90, 120, 150, and 180 min. Area under the curve for glucose and insulin were higher (P ≤ 0.05) following CAF than both PL and DECAF and, although a similar trend (P = 0.07) was observed following RCOF compared with DECAF, the effect was less pronounced. Interestingly, DECAF resulted in a 50% lower glucose response (P ≤ 0.05) than PL, suggesting that the effects of PL and DECAF on glucose tolerance are not the same. These findings suggest that the effects of CAF and RCOF are not identical and may provide a partial explanation as to why acute CAF ingestion impairs glucose tolerance while chronic RCOF ingestion protects against type 2 diabetes.
לסיכום:
צריכת קפה (לא קפאין) באופן כרוני משפרת את הרגישות לאינסולין ולכאורה מניעת סכרת מסוג II.
מדובר לא בקפאין אלה בחומרים אחרים שנמצאים בקפה כמו פוליפנולים, פיטוכמיקלים נוגדי חמצון (אנטי אוקסידנטים). צריכה בצורה סייקלסטית של קפאין יתן את אפקט המרץ ועירנות, תוריד את הרגישות לאנסולין, ותסייע לירידת/שמירת משקל.
