נק' מוניטין:
58,703
בשפה לא מדעית:
http://www.eurekalert.org/pub_releases/2015-01/mu-cob011415.php
בשפה מדעית:
Cell. 2015 Jan 15;160(1-2):88-104. doi: 10.1016/j.cell.2014.12.022.
Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat.
Dodd GT1, Decherf S1, Loh K1, Simonds SE2, Wiede F1, Balland E2, Merry TL1, Münzberg H3, Zhang ZY4, Kahn BB5, Neel BG6, Bence KK7, Andrews ZB2, Cowley MA2, Tiganis T8.
Author information
Abstract
The primary task of white adipose tissue (WAT) is the storage of lipids. However, "beige" adipocytes also exist in WAT. Beige adipocytes burn fat and dissipate the energy as heat, but their abundance is diminished in obesity. Stimulating beige adipocyte development, or WAT browning, increases energy expenditure and holds potential for combating metabolic disease and obesity. Here, we report that insulin and leptin act together on hypothalamic neurons to promote WAT browning and weight loss. Deletion of the phosphatases PTP1B and TCPTP enhanced insulin and leptin signaling in proopiomelanocortin neurons and prevented diet-induced obesity by increasing WAT browning and energy expenditure. The coinfusion of insulin plus leptin into the CNS or the activation of proopiomelanocortin neurons also increased WAT browning and decreased adiposity. Our findings identify a homeostatic mechanism for coordinating the status of energy stores, as relayed by insulin and leptin, with the central control of WAT browning.
http://www.eurekalert.org/pub_releases/2015-01/mu-cob011415.php
בשפה מדעית:
Cell. 2015 Jan 15;160(1-2):88-104. doi: 10.1016/j.cell.2014.12.022.
Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat.
Dodd GT1, Decherf S1, Loh K1, Simonds SE2, Wiede F1, Balland E2, Merry TL1, Münzberg H3, Zhang ZY4, Kahn BB5, Neel BG6, Bence KK7, Andrews ZB2, Cowley MA2, Tiganis T8.
Author information
Abstract
The primary task of white adipose tissue (WAT) is the storage of lipids. However, "beige" adipocytes also exist in WAT. Beige adipocytes burn fat and dissipate the energy as heat, but their abundance is diminished in obesity. Stimulating beige adipocyte development, or WAT browning, increases energy expenditure and holds potential for combating metabolic disease and obesity. Here, we report that insulin and leptin act together on hypothalamic neurons to promote WAT browning and weight loss. Deletion of the phosphatases PTP1B and TCPTP enhanced insulin and leptin signaling in proopiomelanocortin neurons and prevented diet-induced obesity by increasing WAT browning and energy expenditure. The coinfusion of insulin plus leptin into the CNS or the activation of proopiomelanocortin neurons also increased WAT browning and decreased adiposity. Our findings identify a homeostatic mechanism for coordinating the status of energy stores, as relayed by insulin and leptin, with the central control of WAT browning.
