תזונה ותוספים Effects of two energy-restricted diets differing in the carbohydrate/protein ratio on

[Mike Bikov]

Int J Food Sci Nutr. 2008 Jul 25:1-13. [Epub ahead of print]
Effects of two energy-restricted diets differing in the carbohydrate/protein ratio on weight loss and oxidative changes of obese men.Abete I, Parra D, Martinez De Morentin B, Alfredo Martinez J.
Department of Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain.

Introduction Low-carbohydrate, high-protein diets are a current challenge in the nutritional treatment of obesity. Objective To compare the effect of a low-carbohydrate high-protein diet with a traditional hypocaloric diet on weight loss and mitochondrial oxidative metabolism. Subjects and methods Nineteen obese men (age 36+/-6 years; body mass index 34+/-2 kg/m(2)) were randomized to follow one of the two diets-control diet (15% protein; 30% lipids; 55% carbohydrates) or high-protein diet (30% protein; 30% lipids; 40% carbohydrates)-over an 8-week period. Anthropometry, biochemical variables, resting energy expenditure and mitochondrial oxidation were measured at the start and at the end of the intervention. Results The high-protein diet produced a greater weight loss (-8.3+/-1.2% versus -5.5+/-2.5%, P=0.012) than the control diet. Interestingly, an activation in the mitochondrial oxidation was found in the high-protein-fed group. This stimulation was positively correlated with the final resting energy expenditure and negatively associated with the final fat mass content. Conclusion Low-carbohydrate high-protein diets could involve specific changes in mitochondrial oxidation that could be related to a higher weight loss.

PMID: 18654910 [PubMed - as supplied by publisher]

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