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Physical Activity Offsets the Negative Effects of a High Fructose Diet.
AuthorsBidwell AJ, et al. Show all Journal
Med Sci Sports Exerc. 2014 May 20. [Epub ahead of print]
Affiliation
Abstract
OBJECTIVE: To determine the interaction between a high fructose diet and PA levels on postprandial lipidemia and inflammation in normal weight, recreationally active individuals.
METHODS: Twenty-two men and women (age: 21.2 ± 0.6 yrs; BMI = 22.5 ± 0.6 kg/m) consumed an additional 75 g of fructose for 14 days on two separate occasions: high physical activity (∼12,500 steps/day: FR+Active) and low PA (∼ 4,500 steps/day; FR+Inactive). A fructose-rich test meal was given prior to and at the end of each intervention. Blood was sampled at baseline and for 6 h after the meal for triglycerides (TG), very-low density lipoproteins (VLDL), total cholesterol (TC), glucose, insulin, tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) and c-reactive protein (CRP).
RESULTS: Log transformed TG AUC significantly increased from pre (10.1 ± 0.1 mg/dL x min for 6 h) to post (10.3 ± 0.08 mg/dL x min for 6 h; p = 0.04) in the FR+Inactive intervention with an 88% increase in Δpeak[TG] (p=0.009) and an 84% increase in Δpeak[VLDL] (p=0.002). Δpeak[IL-6] also increased by 116% after FR+Inactive intervention (p=0.009). Insulin tAUC significantly decreased after FR+Active intervention (p=0.04) with no change in AUC after the FR+Inactive intervention. No changes were observed in glucose, TNF-α and CRP concentrations (p>0.05).
CONCLUSIONS: Low physical activity during a period of high fructose intake augments fructose-induced postprandial lipidemia and inflammation while high PA minimizes these fructose-induced metabolic disturbances. Even within a young healthy population, maintenance of high PA (>12500 steps/day) decreases susceptibility to cardiovascular risk factors associated with elevated fructose consumption.
AuthorsBidwell AJ, et al. Show all Journal
Med Sci Sports Exerc. 2014 May 20. [Epub ahead of print]
Affiliation
Abstract
OBJECTIVE: To determine the interaction between a high fructose diet and PA levels on postprandial lipidemia and inflammation in normal weight, recreationally active individuals.
METHODS: Twenty-two men and women (age: 21.2 ± 0.6 yrs; BMI = 22.5 ± 0.6 kg/m) consumed an additional 75 g of fructose for 14 days on two separate occasions: high physical activity (∼12,500 steps/day: FR+Active) and low PA (∼ 4,500 steps/day; FR+Inactive). A fructose-rich test meal was given prior to and at the end of each intervention. Blood was sampled at baseline and for 6 h after the meal for triglycerides (TG), very-low density lipoproteins (VLDL), total cholesterol (TC), glucose, insulin, tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) and c-reactive protein (CRP).
RESULTS: Log transformed TG AUC significantly increased from pre (10.1 ± 0.1 mg/dL x min for 6 h) to post (10.3 ± 0.08 mg/dL x min for 6 h; p = 0.04) in the FR+Inactive intervention with an 88% increase in Δpeak[TG] (p=0.009) and an 84% increase in Δpeak[VLDL] (p=0.002). Δpeak[IL-6] also increased by 116% after FR+Inactive intervention (p=0.009). Insulin tAUC significantly decreased after FR+Active intervention (p=0.04) with no change in AUC after the FR+Inactive intervention. No changes were observed in glucose, TNF-α and CRP concentrations (p>0.05).
CONCLUSIONS: Low physical activity during a period of high fructose intake augments fructose-induced postprandial lipidemia and inflammation while high PA minimizes these fructose-induced metabolic disturbances. Even within a young healthy population, maintenance of high PA (>12500 steps/day) decreases susceptibility to cardiovascular risk factors associated with elevated fructose consumption.
