תזונה ותוספים Effect of weight loss by a LF diet and a LC diet on peptide YY levels

[Mike Bikov]

Int J Obes (Lond). 2010 Mar 30. [Epub ahead of print]

Effect of weight loss by a low-fat diet and a low-carbohydrate diet on peptide YY levels.

Essah PA, Levy JR, Sistrun SN, Kelly SM, Nestler JE.

Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.

Objective:To compare the effects of weight loss by an energy-restricted low-fat diet vs low-carbohydrate diet on serum peptide YY (PYY) levels.Design:8-week prospective study of 30 obese adults (mean age: 42.8+/-2.0 years, mean body mass index 35.5+/-0.6 kg m(-2)).Results:After 8 weeks, subjects on the low-carbohydrate diet lost substantially more weight than those on the low-fat diet (5.8 vs 0.99 kg, P<0.001). Weight loss by either diet resulted in a 9% reduction in both mean fasting serum PYY levels (baseline: 103.5+/-8.8 pg ml(-1), after weight loss: 94.1+/-6.5 pg ml(-1), P<0.01) and postprandial area under the curve (AUC) PYY (baseline: (20.5+/-1.5) x 10(3) pg h(-1) ml(-1), after weight loss: mean AUC PYY (18.8+/-1.4) x 10(3) pg h(-1) ml(-1), P<0.001). There was a trend towards lower levels of PYY with greater degrees of weight loss.Conclusions:Reduced PYY levels after weight loss by an energy-restricted low-fat or low-carbohydrate diet likely represents a compensatory response to maintain energy homeostasis and contributes to difficulty in weight loss during energy-restricted diets​

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