תזונה ותוספים Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synth

[Mike Bikov]

First published December 15, 2010, doi: 10.3945/​ajcn.110.005611
Am J Clin Nutr December 2010 ajcn.005611

Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial1,2,3
Gordon I Smith, Philip Atherton, Dominic N Reeds, B Selma Mohammed, Debbie Rankin, Michael J Rennie, and Bettina Mittendorfer
+ Author Affiliations

1From the Washington University, School of Medicine, St Louis, MO (GIS, DNR, BSM and BM), and the University of Nottingham, School of Graduate Entry Medicine and Health, Derby, United Kingdom (PA, DR, and MJR).
↵2 This publication was made possible by grant number UL1 RR024992 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH); NIH grants AR 49869, RR 00954 (Biomedical Mass Spectrometry Resource), and DK 56341 (Nutrition and Obesity Research Center); the UK Biotechnology and Biological Sciences Research Council grants BB/XX510697/1 and BB/C516779/1; a European Union EXEGENESIS program grant; and grants from Reliant Pharmaceuticals Inc and the Longer Life Foundation. GIS was supported by an Ellison Medical Foundation/American Federation for Aging Research Postdoctoral Fellowship. PA is a designated Research Councils UK fellow. DNR was supported by an American Society of Nutrition Physician Nutrition Support Specialist Award.

↵3 Address correspondence to B Mittendorfer, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 660 South Euclid Avenue; Campus Box 8031, Saint Louis, MO 63110. E-mail: [email protected].

Abstract

Background: Loss of muscle mass with aging is a major public health concern. Omega-3 (n–3) fatty acids stimulate protein anabolism in animals and might therefore be useful for the treatment of sarcopenia. However, the effect of omega-3 fatty acids on human protein metabolism is unknown.

Objective: The objective of this study was to evaluate the effect of omega-3 fatty acid supplementation on the rate of muscle protein synthesis in older adults.

Design: Sixteen healthy, older adults were randomly assigned to receive either omega-3 fatty acids or corn oil for 8 wk. The rate of muscle protein synthesis and the phosphorylation of key elements of the anabolic signaling pathway were evaluated before and after supplementation during basal, postabsorptive conditions and during a hyperaminoacidemic-hyperinsulinemic clamp.

Results: Corn oil supplementation had no effect on the muscle protein synthesis rate and the extent of anabolic signaling element phosphorylation in muscle. Omega-3 fatty acid supplementation had no effect on the basal rate of muscle protein synthesis (mean ± SEM: 0.051 ± 0.005 compared with 0.053 ± 0.008%/h before and after supplementation, respectively; P = 0.80) but augmented the hyperaminoacidemia-hyperinsulinemia–induced increase in the rate of muscle protein synthesis (from 0.009 ± 0.005%/h above basal values to 0.031 ± 0.003%/h above basal values; P < 0.01), which was accompanied by greater increases in muscle mTORSer2448 (P = 0.08) and p70s6kThr389 (P < 0.01) phosphorylation.

Conclusion: Omega-3 fatty acids stimulate muscle protein synthesis in older adults and may be useful for the prevention and treatment of sarcopenia. This trial was registered at clinical trials.gov as NCT00794079.​

לא יודע, כל החרא סביב אומגה 3 כבר מתחיל להיות ממש הזוי, אני מחכה ליום שיצא מחקר שיוכיח שזה סתם חרא והכל מומן ע"י חברות אומגה 3

 

[אבי כהן]

אתה עושה צחוק?
אפילו המחקר הספציפי הזה ממומן ע"י חברת תרופות שההתמחות והמוצר העיקרי שלה הוא אומגה 3 למבוגרים.
😃

 

[Mike Bikov]

הכוונה שלי הייתה שזה משוחד והתוצאות לא יוצאות כפי שמתואר במחקר, זה שהוא ממון ע"י חברת תרופות כזו או אחרת לא אומר (עדיין) שזה מכור.

עריכה: איפה ראית שרשום שזו מומן ע"י חברת אומגה 3 כולשהי? כל המימונים שאני רואה שם זה מילגות וחברות ממשלתיות

 

[אבי כהן]

הבנתי למה אתה מתכוון, סתם רציתי להציק קצת.
Reliant Pharmaceuticals Inc (שנרכשה לא מזמן עי GSK)

 

[Mike Bikov]

הלוואי הכל משוחד, ככה לא צריך יהיה לבלוע 5 כדורים בטעם גומי ריצפה

 

[EMZ]

5? תקנה מינון כפול יא תימני.

 

[Mike Bikov]

מה אני כמוך, זה כפולים של קרלסון