Genetic predictors of antipsychotic-induced weight gain: a case-matched multi-gene st

[Mike Bikov]

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Aug;36(8):720-3.
Genetic predictors of antipsychotic-induced weight gain: a case-matched multi-gene study.

Wu R, Zhao J, Shao P, Ou J, Chang M.
Source

Central South University, Changsha, China.
Abstract

OBJECTIVE:
To determine associations between weight gain induced by antipsychotic and the polymorphisms of HTR2C gene -759C/T and -697G/C, histamine-1 receptor gene, leptine gene -2548G/A, and adiponectin gene +276G/T and +45T/G.

METHODS:
In the case-matched study, 85 patients who gained more than 7% of their pre-drug body weight served as the study group and another 85 patients who gained less than 7% of their pre-drug body weight served as the control group. The ligation diction reaction technique was used to analyze the frequencies of the -759C/T and -697G/C polymorphism of the HTR2C gene, -2548A/G polymorphism of leptin gene, +276G/T and +45T/G polymorphism of adiponectin gene and glu349asp polymorphism of H1 receptor gene.

RESULTS:
The presence of the -759C allele, -697G allele, -2548A allele and +276G allele was significantly higher in the study group than that in the control group (P<0.05).

CONCLUSION:
The -759C/T and -697G/C polymorphisms of the promoter region of 5HT(2)C receptor gene, -2548A/G polymorphisms of leptin gene and +276G/T polymorphisms of adiponectin gene may be associated with the antipsychotic induced weight gain. The glu349asp polymorphisms of histamine-1 receptor gene is not associated with antipsychotic induced weight gain.


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