תזונה ותוספים Association between omega-3 fatty acid supplementation and risk of major cardiovascul

[Mike Bikov]

JAMA. 2012 Sep 12;308(10):1024-33.
Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis.
Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS.

Source
Lipid Disorders Clinic, Department of Internal Medicine, University Hospital of Ioannina, Ioannina, Greece.

Abstract
CONTEXT:
Considerable controversy exists regarding the association of omega-3 polyunsaturated fatty acids (PUFAs) and major cardiovascular end points.

OBJECTIVE:
To assess the role of omega-3 supplementation on major cardiovascular outcomes.

DATA SOURCES:
MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials through August 2012.

STUDY SELECTION:
Randomized clinical trials evaluating the effect of omega-3 on all-cause mortality, cardiac death, sudden death, myocardial infarction, and stroke.

DATA EXTRACTION:
Descriptive and quantitative information was extracted; absolute and relative risk (RR) estimates were synthesized under a random-effects model. Heterogeneity was assessed using the Q statistic and I2. Subgroup analyses were performed for the presence of blinding, the prevention settings, and patients with implantable cardioverter-defibrillators, and meta-regression analyses were performed for the omega-3 dose. A statistical significance threshold of .0063 was assumed after adjustment for multiple comparisons.

DATA SYNTHESIS:
Of the 3635 citations retrieved, 20 studies of 68,680 patients were included, reporting 7044 deaths, 3993 cardiac deaths, 1150 sudden deaths, 1837 myocardial infarctions, and 1490 strokes. No statistically significant association was observed with all-cause mortality (RR, 0.96; 95% CI, 0.91 to 1.02; risk reduction [RD] -0.004, 95% CI, -0.01 to 0.02), cardiac death (RR, 0.91; 95% CI, 0.85 to 0.98; RD, -0.01; 95% CI, -0.02 to 0.00), sudden death (RR, 0.87; 95% CI, 0.75 to 1.01; RD, -0.003; 95% CI, -0.012 to 0.006), myocardial infarction (RR, 0.89; 95% CI, 0.76 to 1.04; RD, -0.002; 95% CI, -0.007 to 0.002), and stroke (RR, 1.05; 95% CI, 0.93 to 1.18; RD, 0.001; 95% CI, -0.002 to 0.004) when all supplement studies were considered.

CONCLUSION:
Overall, omega-3 PUFA supplementation was not associated with a lower risk of all-cause mortality, cardiac death, sudden death, myocardial infarction, or stroke based on relative and absolute measures of association.
PMID: 22968891 [PubMed - indexed for MEDLINE]​

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[ITZIKB]

בקיצור לתסף אומגה 3 לא יעיל??
אולי זה בגלל שזה מתחמצן מהר ונהרס.

 

[Mike Bikov]

בקיצור לתסף אומגה 3 לא יעיל??
אולי זה בגלל שזה מתחמצן מהר ונהרס.

זה לא בדיוק הוכחה, זה סוג של מגמה. קשה עד בלתי אפשרי להוכיח דבר כזה לאורך זמן וצריך מחקר יותר מבוקר ואיכותי, שעולה גם הרבה יותר כסף כמובן.
אומגה 3, נגיד ולא עוזר למחלות לב, אבל יש לו תפקידים רבים ולכן לא הייתי שולל אותו כל כך מהר.