אימונים The champions' mitochondria: Is it genetically determined? A review on mitochondrial

[Mike Bikov]

Physiol Genomics. 2011 May 3. [Epub ahead of print]
The champions' mitochondria: Is it genetically determined? A review on mitochondrial DNA and elite athletic performance.
Eynon N, Moran M, Birk R, Lucia A.
Source

Ariel University Center, Israel.
Abstract

Aerobic ATP generation by the mitochondrial respiratory oxidative phosphorylation system (OXPHOS) is a vital metabolic process for endurance exercise. Notably, mitochondrial DNA (mtDNA) codifies 13 out of the 83 polypeptides implied in the respiratory chain. As such, there is a strong rationale for identifing an association between mtDNA variants and 'aerobic' (endurance) exercise phenotypes. This review aim is to summarise the current knowledge on the association between mtDNA, nuclear genes involved in mitochondriogenesis, and elite endurance athletic status. Several studies in non-athletic people have demonstrated an association between certain mtDNA lineages and aerobic performance, charecterized by maximal oxygen uptake (VO(2)max). Whether mtDNA haplogroups are also associated with the status of being an elite endurance athlete is more controversial, with differences between studies arising from the different ethnic background of the athletic cohorts (Caucasian of mixed geografic origin, Asiatic or East-African).

PMID:
21540298
[PubMed - as supplied by publisher]​

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